The Golden Helix Foundation has been established in 2003 as an international non-profit scientific research organization with interdisciplinary research and educational activities in the field of genome medicine.

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The Golden Helix Academy is part of the educational activities of the Golden Ηelix Foundation. The Golden Helix Academy provides training in the field of Genomic and Precision Medicine offering different type of training as outline below:

 

 

 

E-learning training modules

1. E-learning training modules related to Genomic Medicine topics, such as: Personalised Medicine, Economics and Health Technology Assessment in Genomics, Nutrigenomics, bioinformatics.

These modules are provided in English, as well as in local languages, where applicable. They are available every trimester and are designed for healthcare professionals and biomedical scientists, who wish to enrich their knowledge on these emerging disciplines and lead to academic Certificates

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The following e-learning training modules are currently available:

 

Introduction to Bioinformatics for clinical genome interpretation

Introduction to Bioinformatics for clinical genome interpretation

 

Instructor: Dr. Darrol J. Baker; The Golden Helix Foundation, London, UK

 

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Course overview

This is a practical course in Bioinformatics, which will emphasize how to use the computer as a tool for biomedical research. Prerequisites include a thorough understanding of theoretical and practical aspects of molecular biology, and a medium level of mathematics and statistics, but no prior knowledge of computer programming or computer hardware is necessary.

Bioinformatics has now firmly established itself as a discipline in molecular medicine, and encompasses a wide range of subject areas from structural biology, genomics to gene expression studies and personalised medicine. In this course we will learn how algorithms, databases and popular software tools are used to answer these and many other questions in modern clinical genomic biology as well as applying them to real world whole human genomes experimental datasets for understanding and interpretation. We will take the user from a beginner level understanding to one that can analysis multiple whole human genomes and derive meaningful clinical results using the latest methodologies.

The first part of the course includes an introduction to bioinformatics the discipline of Pharmacogenomics, accompanied by an historical perspective. This part also refers to the analytical methods used in pharmacogenomic testing.

The second part of the course includes a comprehensive overview of databases used within the field of bioinformatics for clinical data understanding and the power of relational databases within this setting. The final part covers algorithms for solving various biological problems along with a handful of programming challenges helping you implement these algorithms using Perl and Python.

The third part of the course will cover algorithms for solving various biological problems along with a handful of programming challenges helping you implement these algorithms in Python. Lasty, this places these techniques in a clinical setting for the understanding of clinical genomes and patient diagnosis.

The fourth part of this course covers more advanced techniques for genome manipulation and understanding that are crucial in personalized medicine and tailoring ones genome understanding within a clinical setting.

The fifth and final part of the course is dedicated to clinical genomics and bioinformatics understanding within a clinical or healthcare settings. Dealing with patient data and presenting clinical findings to clinicians, healthcare workers and patients. Finally, an understanind of data securirty, ethics and future directions in genome and personalised medicine.

 

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Duration: 3 months

 

Table of Contents

1.1 The Role of Bioinformatics in Clinical Genomics

1.2 Introducing Clinical Genomics Databases

1.3 Introducing Alignments, BLAST and Perl

1.4 Further Alignment with Perl for the Clinic

1.5 Multiple Sequence Alignments (MSA) and Perl in Clinical Genomics.  

1.6 Clinical Phylogenetic Analysis

1.7 Introduction to Clinical Genomics

1.8 Advanced Clinical Genomics: Microarray Analysis

1.9 Clinical Next Generation Sequencing (NGS)

1.9.1 Loading Sequence

1.9.2 Manipulation and Analysis

1.10 Advance Clinical NGS Analysis

1.10.1 Sequence Variation

1.10.2. Commercial Genomics

1.11 Clinical NGS 1: The importance of ChIP-seq

1.12 Clinical NGS 2: The importance of RNA-seq

1.13 Clinical NGS: Personalised and Stratified Medicine.

1.14 Future Directions in Clinical Medicine

 

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Evaluation

The overall evaluation of the students will be based on the assessment of a task that will be related to the topics discussed in this course. 

 

 

Economic Evaluation in Genomic Medicine

Economic evaluation in Genomic Medicine

 

Instructor: Dr. Vasilis Fragoulakis; The Golden Helix Foundation, London, UK

 

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Course overview 

The first section provides the definition of economic evaluation in health services and its relation to the economic science. It also discusses whether or not personalized medicine can coexist with the economic evaluation, what are the points that they intersect and why it is necessary to make economic assessments. At the same time, the methodology of the economic evaluation is outlined combined with examples of application in medical practice. In particular, the methodology includes an introduction to the method of economic evaluation, the various aspects of cost-effectiveness analysis with regard to alternative approaches, accompanied by specific examples in medical practice, the appropriate measure of cost-effectiveness analysis and the evaluation criteria that are used in health.

The second section discusses the decision criteria based on the cost-effectiveness analysis, from which the final decision to adopt or reject new technology, new therapy, or innovative drug, is derived. In addition, there are various ways of assessing the quality of life in cost-utility analysis and utility estimation methods. This section ends with the summary of the disadvantages and the assumptions of the cost-utility analysis.

In the third section, the most important technical issues related to the economic evaluation are summarized. In particular, the definition of the willingness to pay (λ) and how it is calculated in different countries is presented, along with the different types of economic models and their use as practical tools for making and implementing political decisions.

In the fourth and final section, the principles of economic analysis in personalized medicine are thoroughly analyzed. In particular, the various economic models used in personalized medicine are presented, both in prospective and in retrospective studies. Also, reference is made to the concept of measurable efficacy in personalized medicine, while detailed examples and standard economic assessment studies in pharmacogenomics and personalized medicine are discussed. Finally, the challenges of the economic assessment in the field of personalized medicine and the future perspectives of this discipline are summarized.

  

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Duration: 3 months

 

Table of contents

1. Economic science, the framework for the application of economic assessment to the health care services. Economic science and its relationship to personalized medicine.

2. Introduction to health economics, the types of assessment criteria that are used in healthcare and the need to produce financial assessments.

3. Introduction to the method of economic evaluation, examples of economic evaluation in medical practice.

4. Decision criteria based on cost-effectiveness analysis. The final decision to adopt or reject a new technology, new therapy or innovative drug.

5. Assessing the quality of life in cost-utility analysis and utility estimation methods. Disadvantages in cost-utility analysis.

6. Important technical issues in the economic evaluation. The value of λ in different countries. How much does it cost a year of life?

7. Cost estimation in economic studies. Types of economic models in economic analysis. Sensitivity analysis.

8. Economic analysis and economic models in personalized medicine.

9. Measurable effectiveness in personalized medicine. Examples of economic evaluation in personalized medicine.

10. Challenges of economic evaluation in the field of personalized medicine.

11. Conclusions and future prospects.

 

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Evaluation

The overall evaluation of the students will be based on the assessment of a task that will be related to the topics discussed in this course. 

 

Pharmacogenomics in Clinical Care and Drug Discovery

Pharmacogenomics in clinical care and drug discovery

 

Instructor: Prof. Dr. George P. Patrinos; University of Patras, Department of Pharmacy, Patras, Greece

 

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Course overview

Pharmacogenomics is the cornerstone of Genomic and Precision Medicine, aiming to redefine disease management and patient stratification. As such, pharmacogenomic testing becomes fundamental to the development and clinical use of several molecular diagnostics as well as targeted therapies. Notwithstanding, there are still barriers (scientific, economic, educational, ethical, legal) that need to be overcome prior to the application of pharmacogenomic technologies towards innovative clinical strategies and optimized therapeutic outcomes. For this to be achieved, continued research as well as the participation of all involved stakeholders becomes critical. This course aims to summarize the current knowledge on how the discipline of genetics and genomics can influence drug discovery and development, and more broadly to the practice of health care.

The first part of the course includes an introduction to the discipline of Pharmacogenomics, accompanied by an historical perspective. This part also refers to the analytical methods used in pharmacogenomic testing.

The second part of the course includes examples from the clinical applications of pharmacogenomics. In particular, examples of use cases in oncology, cardiology, psychiatry, infectious diseases, transplantation, etc are discussed, focusing in particular on the corresponding drug-gene-pharmacogenomic biomarker combinations, focusing in particular on the required dose adjustements.

The third part of the course discusses the impact of population differences in the prevalence of pharmacogenomic biomarkers and their role in population pharmacogenomics. It also alludes to the complex phenotypes and rare drug outcomes resulting from rare pharmacogenomic variants. Lastly, this part summarizes the various regulatory aspects of pharmacogenomics and their role in drug development.

The fourth part of this course provides an outline of databases and other useful resources for Pharmacogenomics, such as the PharmGKB knowledgebase, etc. It also discusses the various new trends in the pharmacogenomics field, such as pharmacometabolomics-aided pharmacogenomics and the application of whole genome sequencing in pharmacogenomics.

The fifth and final part of the course is dedicated to the various ethical aspects of pharmacogenomics and the implications of the accompanying pharmacogenomics-related legislation. Lastly, this part discusses the role and impact of Pharmacogenomics on public health.

 

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Duration: 3 months

 

Table of contents 

1. Introduction and history of Pharmacogenomics

2. Analytical methods in Pharmacogenomics

3. Pharmacogenomics in clinical settings – Oncology

4. Pharmacogenomics in clinical settings – Cardiology

5. Pharmacogenomics in clinical settings – Psychiatry and Infectious diseases

6. Population differences and complex phenotypes in pharmacogenomics

7. Regulatory aspects of pharmacogenomics and its role in drug development

8. Useful resources for Pharmacogenomics

9. New trends in Pharmacogenomics

9.1. Pharmacometabolomics-aided pharmacogenomics

9.2. Pharmacogenomics and whole genome sequencing

10. Ethical aspects of pharmacogenomics and implications

10.1. Pharmacogenomics legislation

10.2. Secondary information

11. Public Health Pharmacogenomics

12. Conclusions and future perspectives

 

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Evaluation

The overall evaluation of the students will be based on the assessment of a task that will be related to the topics discussed in this course. 

  

On-site training courses

 

On-site training courses in Human Genome Informatics are provided on a regular basis in London and aim to provide hands-on experience in basic aspects of human genome informatics. The next available on-site training course is scheduled for mid-May. Exact dates will be announced soon.

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On demand on-site training

On demand on-site training. Apart from the above means of training, the Golden Helix Academy offers the option of on-site training on demand, where experienced instructors provide training of academic or corporate staff on demand at your premises, namely your institution or company in your own country. On demand on-site training course are tailor-made to meet your needs and time schedule. The themes of the on demand onsite training revolve around pharmacogenomics, cancer genomics, economics and Health Technology Assessment, and genome informatics.

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The Golden Helix Foundation has been
established in 2003

as an international non-profit scientific organization with interdisciplinary research and educational activities in the field of genome medicine. The Foundation is engaged in research and educational activities in Europe, Asia, the Middle East and in Latin American countries.
  • 11

    Golden Helix Symposia were organized in the fields of genomic and personalized medicine.
  • 19

    Golden Helix Pharmacogenomics Days aiming to provide timely updates on the field of pharmacogenomics and personalized medicine.
  • 3

    Golden Helix Summer Schools as international educational activities in the field of Precision Medicine & Biomedical informatics.

Publications by the Golden Helix Foundation

Results of research projects and summaries of academic activities of the Golden Helix Foundation have been published in peer-reviewed academic journals.

What makes the Golden Helix Foundation unique?

The Golden Helix Foundation

Innovation

The activities of the Golden Helix Foundation are supervised by an international scientific advisory council, consisting of world leaders...

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Research Activities

The Foundation is involved in multidisciplinary sciientific collaborative projects in the field of translational research. In particular the foundation...

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Academic Rigor

The Foundation organizes high profile scientific symposia in the field of personalized medicine, namely the Golden Helix Symposia. Furthermore...

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