Welcome

2012 Golden Helix Symposium

"Genomic Medicine - Translating genes into health"

Torino Incontra Convention Center, 18-21 April 2012, Turin, Italy

We are very pleased to welcome you to the 2012 GOLDEN HELIX Symposium: Genomic Medicine: Translating Genes into Health
Genomic Medicine is expected to play a key role in future medical practice. Recognizing the challenges that are emerging from the recent advances in genomics and their impact on human health, the GOLDEN HELIX Symposium features lectures by more than 25 internationally renowned scientists and covers all aspects of this field, including recent developments from deciphering the human genome, cancer and population genomics
and the requirements to bring genomics in the clinic.

Turin is a major business and cultural centre in Northern Italy, capital of the Piedmont region. It was the first capital of the unified Italy and it is often referred to as "the Capital of the Alps", "the Automobile Capital of Italy" or the Detroit of Italy. The city has a rich culture and history, and is known for its numerous art galleries, restaurants, churches, palaces, opera houses, piazzas, parks, gardens, theatres, libraries, museums and other venues. Turin is well-known for its Royal Palace of Turin, the Palazzina di caccia of Stupinigi and the Basilica di Superga and hosts some of Italy's best universities, colleges, academies, lycea and gymnasia, such as the Polytechnic University of Turin. Prestigious and important museums, such as the Museo Egizio and the Mole Antonelliana are also found in the city. Also, Turin is well known as the home of the Shroud of Turin and the headquarters of automobile manufacturers Fiat, Lancia and Alfa Romeo. In 2006, the city hosted the 2006 Winter Olympic Games. Following the successful organization of the previous Golden Helix Symposia in Athens, Greece, the 2012 Golden Symposium will again revolve around translational medicine.

We are committed to setting the highest standard for symposia in the field of human genomics and personalized medicine, and look forward to welcoming you to Turin in April.

The 2012 Golden Helix Symposium Organizing Committee

Co-organized by:

Endorsed by:

Venue

2012 Golden Helix Symposium Venue

The venue of the 2012 Golden Helix Symposium is the Torino Incontra Convention Center.

A functional and technologically advanced structure characterized by professionalism and elegance besides a wide range of spaces suitable for conferences, conventions and big events. Torino Incontra is all this right in the heart of the city of Turin with plenty of leisure, shopping art and culture options. Easy access to town from motorways, airport and a few minutes away from the railway and the underground.

Speakers

Organizing committee

George P. Patrinos - University of Patras, Greece
Federico Innocenti - University of North Carolina, Chapel Hill, NC, USA
Paolo Fortina - Thomas Jefferson University, Philadelphia, PA, USA

Invited Speakers

Najib Al-Khaja (Dubai, UAE)
Myles Axton (New York, NY, USA)
Francis Barany (New York, NY, USA)
John Burn (Newcastle, UK)
Gianpiero Cavalleri (Dublin, IE)
Ioannis Charalampopoulos (Crete, GR)
Allen Chang (Hong Kong, CN)
Carlo Croce (Columbus, OH, USA)
Garry Cutting (Baltimore, MD, USA)
Silvia Deaglio (Turin, IT)
Radoje Drmanac (Mountain View, CA, USA)
Elaine Dzierzak (Rotterdam, NL)
Jim Eberwine (Philadelphia, PA, USA)
Chun Fang Xu (Hertfordshire, UK)
Henk-Jan Guchelaar (Leiden, NL)
Eileen Hoal (Matieland, SA)
Vanessa Hayes (La Jolla, CA, USA)
Erik Knudsen (Philadelphia, PA, USA)
Larry J. Kricka (Philadelphia, PA, USA)
Mark Lathrop (Quebec, CA)
Elliott Margulies (Cambridge, UK)
Giuseppe Matullo (Turin, IT)
Salvatore Oliviero (Siena, IT)
lberto Piazza (Turin, IT)
Isidore Rigoutsos (Philadelphia, PA, USA)
Hilger Ropers (Munich, DE)
Yvonne Tay (Cambridge, MA, USA)
Ian Tomlinson (Oxford, UK)
Ron van Schaik (Rotterdam, NL)
Paolo Vineis (London, UK)

Scientific Program

WEDNESDAY, APRIL 18, 2012

13:00-17:30 DELEGATE REGISTRATION

18:00-20:00 WELCOME COCKTAIL

THURSDAY, APRIL 19, 2012

08:30-08:45 OPENING ADDRESS
Piero Gastaldo, Compagnia di San Paolo, Turin, Italy

Organizing committee:
George Patrinos, Federico Innocenti, Paolo Fortina

SESSION 1 NEW DEVELOPMENTS IN DECODING THE HUMAN GENOME
Chair: Paolo Fortina, George P. Patrinos

08:45-09:15 Pattern discovery and novel categories of non-coding RNAs
Isidore Rigoutsos, PhD
Center for Computational Medicine, Thomas Jefferson University, Philadelphia, PA, USA

09:15-09:45 Programming hematopoietic stem cell fate
Elaine Dzierzak, PhD
Erasmus MC, Stem Cell Institute, Rotterdam, NL

09:45-10:30 Keynote lecture I (introduction by George P. Patrinos)
Sir John Burn, MD, PhD
Newcastle University, Newcastle, UK

10:30-10:45 COFFEE BREAK

10:45-11:15 Single Cell Genomics:Insights into neuronal functioning
Jim Eberwine, PhD
University of Pennsylvania, Penn Genome Frontiers Institute, Philadelphia, PA, USA

11:15-11:45 Increased accuracy and utility of whole-genome sequencing analyses for biomedical interpretations
Elliott Margulies, PhD
Illumina Ltd, Cambridge, UK

11:45-12:15 Large-scale accurate personal genome sequencing and interpretation to enable genomic medicine
Radoje Drmanac, PhD
Complete Genomics Inc., Mountain View, CA, USA

12:15-13:15 LUNCH BREAK

COMPANYLECTURE SESSIONA (Chair: Alessio Squassina)
13:15-13:45 AGILENT TECHNOLOGIES: Agilent Genomic portfolio for clinical research
Valentina Maran, PhD
Product Specialist Genomic, Agilent Tchnologies Inc
13:45-14:15 ILLUMINA: Illumina Next Generation Sequencing: From research to routine clinical diagnostics
Marco P. Cappelletti, PhD
Illumina Ltd, UK

14:15-15:00 COFFEE BREAK with POSTER SESSION A

SESSION 2 DISCOVERY IN CLINICAL GENOMICS
Chair: Maurizio Ferrari, Federico Innocenti

15:00-15:30 Genomics of epilepsy
Gianpiero Cavalleri, MD
Royal College Surgeons, Dublin, IE

15:30-16:00 Aneuploidy detection during pregnancy by non-invasive fetal DNA measurement
Allen Chang, MD, PhD
The Chinese University of Hong Kong, New Territories, Hong Kong

16:00-16:30 Genetics of cognitive disorders and intellectual disabilities
H. Hilger Ropers, MD
Max Planck Institute for Molecular Genetics, Berlin, Germany

16:30-17:00 Neurotrophins as therapeutic targets for neurodegenerative disorders
Ioannis Charalampopoulos, PhD
University of Crete, School of Medicine, Crete, Greece

17:00-17:30 Myc-dependent epigenetic modifications in cell differentiation and trasformation
Salvatore Oliviero, PhD
Human Genetics Foundation (HuGeF) and Universit di Siena, Italy

19:30-22:00 DINNER/WINE TASTING EVENT (By invitation only)

FRIDAY, APRIL 20, 2012

08:30-08:45 OPENING
George P. Patrinos, Organizing committee, University of Patras, Department of Pharmacy, Patras, Greece

SESSION 3 POPULATION GENOMICS
Chair: Alberto Piazza, Giuseppe Novelli

08:45-09:15 Genomics of infectious diseases in Africa
Eileen Hoal, PhD
Stellenbosch University, South Africa

09:15-09:45 Indigenous populations
Vanessa Hayes, PhD
J Craig Venter Institute, La Jolla, CA, USA

09:45-10:30 Keynote Lecture II (introduction by Larry J. Kricka)
Ian Tomlinson, PhD
The Wellcome Trust, Oxford, UK

10:30-10:45 COFFEE BREAK

10:45:11:15 Population genomics in Italy
Alberto Piazza, MD, PhD
Human Genetics Foundation (HuGeF), Turin, Italy

11:15-11:45: Translating allelic heterogeneity to clinical practice:The CFTR2 project
Garry Cutting, MD, PhD
Johns Hopkins University School of Medicine, Baltimore, MD, USA

11:45-12:15 Incentives for data sharing and collaborative research in genomics
Myles Axton, PhD,
Nature Genetics, New York, NY, USA

12:15-13:00: LUNCH BREAK with POSTER SESSION B

13:00-14:00: WORKSHOP (Organized by Agilent Technologies)

COMPANYLECTURE SESSIONB (Chair: Alessio Squassina)
14:00-14:30 ROCHE DIAGNOSTICS: Genome prescriptions in kidney diseases
Sabrina Giglio, PhD
University of Florence, Medical Genetics, Department of Clinical Pathophysiology, Florence, Italy
14:30-15:00 LIFE TECHNOLOGIES: Ion Torrent semiconductor sequencing, a revolution in the revolution
Raimo Tanzi, PhD
Life Technologies, NGS business development, Europe

SESSION 4 CANCER GENOMICS
Chair: Ettore Capoluongo, Lucio Luzzatto

15:00-15:30 MicroRNAs as therapeutic targets in cancer
Carlo Croce, MD, PhD
Ohio State University, USA

15:30-16:00 Molecular profiling of colon cancer
Francis Barany, PhD
Weill Cornell Medical College, New York, NY, USA

16:00-16:15 COFFEE BREAK

16:15-16:45 An old tumor suppressor: Offering new directions for therapy
Erik Knudsen, PhD
Thomas Jefferson University, Philadelphia, PA, USA

16:45-17:15 Cancer outcome in therapy
Federico Innocenti, MD, PhD
University of North Carolina, Chapel Hill, NC, USA

17:15-17:45 Deconvoluting the PTEN ceRNA network
Yvonne Tay PhD
Beth Israel Deaconess Medical Center, Harvard Medical School, Cambridge, MA, USA

17:45-18:15 The ectoenzyme network as emerging regulator of homing and immune function in the leukemic environment
Silvia Deaglio, MD, PhD
Human Genetics Foundation (HuGeF) and Universit di Torino, Turin, Italy

EVENING FREE

SATURDAY, APRIL 21, 2012

08:30-08:45 OPENING
Federico Innocenti, Organizing committee, University North Carolina at Chapel Hill, NC, USA

SESSION 5 BRINGING GENOMICS TO THE CLINIC
Chair: Giuseppe Saglio, Giuseppe Toffoli

08:45-09:15 Guidelines for implementation of pharmacogenomics
Henk-Jan Guchelaar, PhD
Leiden University Medical Center, Leiden, NL

09:15:09:45 Genomics and drug development
Chun Fang Xu, PhD
Glaxo Smithkline Research, Hertfordshire, UK

09:45:10:15 DNA repair genotype-phenotype correlation: from cancer risk to therapy response
Giuseppe Matullo, PhD
Human Genetics Foundation (HuGeF) and Universit di Torino, Italy

10:15:10:45 Results of GWAS and germline whole genome sequencing: Are they clinically actionable?
Mark Lathrop, PhD
Centre dtude du Polymorphism Humain, Paris, FR

10:45-11:00 COFFEE BREAK

BEST POSTER AWARDS (Chair: George P. Patrinos)
11:00-11:15 Best Poster Award I
11:15-11:30 Best Poster Award II

11:30-13:00 PANEL DISCUSSION (Chair: Larry J. Kricka)
Introducing genomics to the bedside: Scientific, business, ethical prospects and challenges

- Larry J Kricka, PhD, University of Pennsylvania, Philadelphia, PA, USA
- Sir John Burn, MD, PhD, University of Newcastle, UK
- Paolo Vineis, MD, PhD, Human Genetics Foundation (HuGeF) and Imperial College London, UK
- Ron van Schaik, PhD, Erasmus MC, Rotterdam, NL
- Najib Al Khaja, MD, PhD, Cetner for Arab Genomic Studies, Dubai, UAE

13:00-13:15 Closing Remarks and Future Meetings

MEETING ENDS

OPTIONAL EXCURSION